A growing number of stars are speaking out about their connection, or lack of a connection, to the Ozempic craze.
The skinny shot, along with similar GLP-1 medications like Mounjaro and Wegovy, was originally designed to help manage diabetes. But it has since become Hollywood’s most controversial weight loss shortcut.
While some celebrities openly credit weight-loss medication for their slimmed-down physiques, others insist their transformations come from old-fashioned methods, like diet and exercise.
Here’s a look at the stars who have spoken about adding or refusing to add Ozempic to their weight loss regimen.
#21 Jessica Simpson
Fans constantly point fingers at Jessica Simpson for apparently being too skinny and taking Ozempic.
The pop singer denied using GLP-1 medication while addressing the claims during a 2023 interview with Bustle.
“Oh, Lord. I mean, it is not [Ozempic],” she said. “It’s willpower.”
“I’m like, do people want me to be drinking again? Because that’s when I was heavier,” she continued. “Or, they want me to be having another baby? My body can’t do it.”
The mother-of-three, who stopped drinking in 2017, said it “hurts” to see the negative comments but said she won’t let it “derail” her.
The pop singer denied using GLP-1 medication while addressing the claims during a 2023 interview with Bustle.
“Oh, Lord. I mean, it is not [Ozempic],” she said. “It’s willpower.”
“I’m like, do people want me to be drinking again? Because that’s when I was heavier,” she continued. “Or, they want me to be having another baby? My body can’t do it.”
The mother-of-three, who stopped drinking in 2017, said it “hurts” to see the negative comments but said she won’t let it “derail” her.
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#22 Katy Perry
Rumors about Katy Perry using Ozempic have been rampant in recent months.
“She’s definitely taking Ozempic!” a social media user claimed after her appearance at iHeartRadio Q102’s Jingle Ball in December.
Another agreed saying, “She is on Ozempic; you can not deny the Ozempic face.”
In the same month, she addressed her biceps, which were “going around the internet,” and said she actually hates working out.
“I love to dance, swim, and do things that don’t feel like working out,” she said.
The Fireworks singer herself poked fun at Ozempic rumors during her 40th birthday bash last October.
To her friends who joined her for the birthday celebration, she gave out goodie bags that included an empty mini-syringe emblazoned with the word OzempiKP.
“She’s definitely taking Ozempic!” a social media user claimed after her appearance at iHeartRadio Q102’s Jingle Ball in December.
Another agreed saying, “She is on Ozempic; you can not deny the Ozempic face.”
In the same month, she addressed her biceps, which were “going around the internet,” and said she actually hates working out.
“I love to dance, swim, and do things that don’t feel like working out,” she said.
The Fireworks singer herself poked fun at Ozempic rumors during her 40th birthday bash last October.
To her friends who joined her for the birthday celebration, she gave out goodie bags that included an empty mini-syringe emblazoned with the word OzempiKP.
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#23 Serena Williams
The internet was screaming "Ozempic" when Serena Williams flaunted her recent postpartum weight loss journey.
“Somehow, now that she’s retired, she looks more in shape than she did when she played. Can somebody say Ozempic?” read a comment on her social media post from December, which captured her lounging on a private jet.
Fans interjected and said at the time, “This is ridiculous. It’s called working out. Maybe try it. You literally see her running all the time.”
Last year, the tennis icon said she lost 10 pounds after she stopped breastfeeding.
“As a mom, I’m actually way more active than what I was during tennis,” she told TODAY.
“Obviously, [with] tennis, I was playing Wimbledons and stuff,” she added. “But, as a mom, I’m gone all day.”
“Somehow, now that she’s retired, she looks more in shape than she did when she played. Can somebody say Ozempic?” read a comment on her social media post from December, which captured her lounging on a private jet.
Fans interjected and said at the time, “This is ridiculous. It’s called working out. Maybe try it. You literally see her running all the time.”
Last year, the tennis icon said she lost 10 pounds after she stopped breastfeeding.
“As a mom, I’m actually way more active than what I was during tennis,” she told TODAY.
“Obviously, [with] tennis, I was playing Wimbledons and stuff,” she added. “But, as a mom, I’m gone all day.”
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#24 Kylie Jenner
Kylie Jenner said she was down to her pre-pregnancy weight during a September interview with British Vogue.
The mother-of-two addressed how people didn’t show her “enough empathy” after giving birth, and she expressed annoyance over people claiming she was taking Ozempic.
“I’m back at the weight I was before I had my daughter and son, and people are putting side by sides of me three months postpartum,” she said in response to the Ozempic rumors.
“I’m like: ‘Does everyone forget that I had two children and I gained 60 pounds both pregnancies?’” she added.
The mother-of-two addressed how people didn’t show her “enough empathy” after giving birth, and she expressed annoyance over people claiming she was taking Ozempic.
“I’m back at the weight I was before I had my daughter and son, and people are putting side by sides of me three months postpartum,” she said in response to the Ozempic rumors.
“I’m like: ‘Does everyone forget that I had two children and I gained 60 pounds both pregnancies?’” she added.
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#25 Khloé Kardashian
“I’m just mad [Ozempic] wasn’t around 10 years ago,” Khloé Kardashian told Bustle in 2024.
When social media users speculated she was taking GLP-1 medication to trim down, she clapped back and demanded people “stop with [their] assumptions.”
“Let’s not discredit my years of working out,” she said in response to a comment on her social media post. “I get up 5 days a week at 6am to train. Please stop with your assumptions.”
The Good American founder revealed that she began working out in the mid-2010s to reel from her divorce with her ex-husband Lamar Odom.
She has not only denied using Ozempic for weight-loss but also slammed critics for constantly assuming that she did.
On an episode of The Kardashians last year, she admitted she would have tried Ozempic if it was available earlier.
“When I was bigger, if they had Ozempic, I probably would have tried it, cause I tried any other thing,” she said on the show.
“I tried any fad weight loss trend except for the real thing that actually works, and that’s a lifestyle change,” she said.
The reality TV star said she eventually fell in love with working out and said it keeps her happy.
“As a byproduct, my body started changing. I loved the way I felt. I loved testing myself and challenging myself. And I’ve been doing it for 10-plus years now, and I love it,” she told Bustle.
“Over the past three years, people are like, ‘You must have gotten surgery because you just lost weight.’ I’m like, ‘It’s been a 10-year journey! What are you talking about?’” she continued. “But even if people get surgery or [get on] the Ozempic craze, I’m like, ‘Who cares!’ As long as people feel good about themselves, who am I to judge? I think it’s ridiculous, the judgment on that.”
When social media users speculated she was taking GLP-1 medication to trim down, she clapped back and demanded people “stop with [their] assumptions.”
“Let’s not discredit my years of working out,” she said in response to a comment on her social media post. “I get up 5 days a week at 6am to train. Please stop with your assumptions.”
The Good American founder revealed that she began working out in the mid-2010s to reel from her divorce with her ex-husband Lamar Odom.
She has not only denied using Ozempic for weight-loss but also slammed critics for constantly assuming that she did.
On an episode of The Kardashians last year, she admitted she would have tried Ozempic if it was available earlier.
“When I was bigger, if they had Ozempic, I probably would have tried it, cause I tried any other thing,” she said on the show.
“I tried any fad weight loss trend except for the real thing that actually works, and that’s a lifestyle change,” she said.
The reality TV star said she eventually fell in love with working out and said it keeps her happy.
“As a byproduct, my body started changing. I loved the way I felt. I loved testing myself and challenging myself. And I’ve been doing it for 10-plus years now, and I love it,” she told Bustle.
“Over the past three years, people are like, ‘You must have gotten surgery because you just lost weight.’ I’m like, ‘It’s been a 10-year journey! What are you talking about?’” she continued. “But even if people get surgery or [get on] the Ozempic craze, I’m like, ‘Who cares!’ As long as people feel good about themselves, who am I to judge? I think it’s ridiculous, the judgment on that.”
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