One of my personal, all time favorites: the anime My New Boss is Goofy. It is presented as a "slice of life" about a man recovering from workplace abuse trauma and re-learning what it's like to be healthy and happy... but it's so much more than that. On top of all sorts of cutesy stuff, it really is a ballad of recovery and hope and the MC's mental illness isn't disregarded or downplayed for comedy as you might expect.
